Fig. 1

Effects of endothelin-1 (ET-1) (black columns) and the combined infusion of BQ-123 and ET-1 (gray columns) on a total peripheral resistance index (TPRI) and b cardiac index (CI). Normal Sprague-Dawley rats (SpD) (left) and streptozotocin diabetic rats (SpD-STZ) (right). Data are the mean ± SEM. Asterisk above column shows significance at P < 0.05 compared to baseline within each animal group; asterisk on line shows significance between groups