Fig. 5

The ultrastructure of myocardial cells in different groups. In the sham-operated group, the myocardial cell appeared normal with intact sarcomeres; mitochondria (m) contain tightly packed cristae. Numerous glycogen granules were present. In the HF group, some parts of the myocardial cell showed intermyofibrillar lysis (arrows) and vesicles of varying size; mitochondria were swollen, and mitochondrial cristae were separated. In the low-dose group, intermyofibrillar lysis improved slightly, but a few mitochondria were still swollen, and mitochondrial cristae were separated. In the medium-dose group, intermyofibrillar lysis disappeared; myofilaments were orderly, and closely and evenly arranged; and the mitochondria contained tightly packed cristae. The high-dose group was simular to that of the medium-dose group, and the electron density of some mitochondria increased (×30,000)