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Table 2 Glucose-6-phosphate dehydrogenase (G6PDH) activity, reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio and thiobarbituric acid-reactive substances (TBARS) levels in control and postconditioned hearts from fed and fasted rats

From: Involvement of energetic metabolism in the effects of ischemic postconditioning on the ischemic-reperfused heart of fed and fasted rats

 

Fed

Fasted

Preischemic

Ischemic

Reperfusion

Preischemic

Ischemic

Reperfusion

C

IPOC

C

IPOC

G6PDH (units/g protein)

1.45 ± 0.24

1.28 ± 0.17

1.01 ± 0.35

2.11 ± 0.32*+

2.09 ± 0.51†

2.31 ± 0.64†

2.25 ± 0.36†

2.27 ± 0.46

GSH/GSSG

14.58 ± 3.49

12.76 ± 1.77

7.92 ± 1.70*

17.69 ± 4.64+

52.96 ± 9.84†

44.66 ± 8.45†

24.38 ± 6.14*†

16.89 ± 2.98*

TBARS (nmol/gww)

7.70 ± 1.09

9.72 ± 1.23

20.73 ± 2.10*

12.12 ± 2.51*+

3.42 ± 0.42†

5.91 ± 0.87†

14.38 ± 1.76*†

15.93 ± 2.51*

  1. Data are the mean ± SEM (n = 8)
  2. Pre-ischemic, at the end of the 25 min equilibration period; ischemic, at the end of the 25 min ischemic period; reperfusion, at the end of the 30 min reperfusion period
  3. C control hearts, IPOC postconditioned hearts, G6PDH glucose-6-phosphate-dehydrogenase, GSH/GSSG reduced glutathione/oxidized glutathione ratio, TBARS thiobarbituric acid-reactive substances
  4. * p < 0.05 compared with pre-ischemic and ischemic hearts in the same nutritional state
  5. † p < 0.05 compared with hearts from fed rats in the same period
  6. + p < 0.05 versus C reperfusion in the same nutritional state
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The Journal of Physiological Sciences

ISSN: 1880-6562

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