Computer-aided analysis of biochemical mechanisms that increase metabolite and proton stability in the heart during severe hypoxia and generate post-ischemic PCr overshoot

Table 3 Positive and negative effects of particular processes/mechanisms recruited in response to severe hypoxia (inhibition of oxidative phosphorylation, OP) in the heart on ATP turnover flux stability, metabolite stability, pH stability, and post-ischemic PCr overshoot

Process	ATP flux stability	Metabolite stability	pH stability	PCr overshoot
Effect of hypoxia with OP only	− − −	− − −	0	0
AG	+++	++	− − −	0
Down-reg.	−	+	++	++
AMP deco.	0	− −	++	+
Parallel act.	0	+	++	+++

OP, oxidative phosphorylation; AG, anaerobic glycolysis; down reg., down-regulation of ATP usage; AMP deco., AMP decomposition; parallel act., (increase in) parallel activation of oxidative phosphorylation; +++, dramatic positive effect; ++, strong positive effect; +, moderate positive effect; 0, no effect; − − −, dramatic negative effect; − −, strong negative effect; −, moderate negative effect

ISSN: 1880-6562