Table 2 Comparison of computer simulations with experimental data

Hypoxia duration (min)

15

12

15

20

15

25

15

Decrease in [PCr] (to % of initial)

14

41

~10

~0

1^c–14^b

0^b–10^c

2–19

Time to 50% decrease of [PCr] (min)

1–2

–

–

1–2

<3

~1

1–2

Decrease in [ATP] (to % of initial)

~50

63

72

2^ab–40^{a, c}

66^c–74^b

50^b–60^c

46–98

Increase in [P _i] (times)

~7

2.8

2.3

–

–

5^b–8^c

3.2–5.8

Decrease in pH (pH units)

0.87

0.38

0.65

0.6^ab–0.9^{a, c}

0.8^c–1.0^b

0.6^b–0.8^c

0.36–0.81

Decrease in RPP, LVDP, or VO₂ (%)

~30

–

–

22^b–56^c

10^c–20^b

30–80

0–50

PCr overshoot (%)

~15

~15

10^b–20^c

3^b–9^c

15–25

0, 12, 5, 22^d