Computer-aided analysis of biochemical mechanisms that increase metabolite and proton stability in the heart during severe hypoxia and generate post-ischemic PCr overshoot

Table 1 Simulated initial (normoxic) and end-of-hypoxia (15 min) values of pH, PCr, ATP, P _i, and ADP in the presence of different processes activated during severe hypoxia in the heart (Modes 1–5)

Conditions	pH	PCr (mM)	ATP (mM)	P_i (mM)	ADP (μM)
Initial state (normoxia) end of hypoxia	7.00	12.22	6.69	2.60	31.7
OP	7.00	0.01	0.02	18.85	220
OP + AG	6.19	0.43	6.41	10.68	260
OP + AG + down-reg.	6.64	2.37	6.57	8.35	123
OP + AG + AMP deco.	6.25	0.25	3.06	15.17	241
OP + AG + parallel act.	6.43	1.00	6.49	9.74	192

OP, oxidative phosphorylation; AG, anaerobic glycolysis; down reg., down-regulation of ATP usage; AMP deco., AMP decomposition; parallel act., (increase in) parallel activation of oxidative phosphorylation

ISSN: 1880-6562