Fig. 4

Simulated time courses of ATP fluxes and metabolite concentrations during normoxia, hypoxia, and recovery after hypoxia in Mode 3 (OP + AG + down-reg.). 0–2 min, normoxia; 2–17 min, hypoxia; 17–45 min, recovery after hypoxia. a time courses of ATP usage and ATP production by oxidative phosphorylation, creatine kinase (CK), and anaerobic glycolysis; b time courses of ATP, ADP, PCr, P _i, and pH