Fig. 2

Simulated time courses of ATP fluxes and metabolite concentrations during normoxia, hypoxia, and recovery after hypoxia in Mode 1 (OP). 0–2 min, normoxia; 2–17 min, hypoxia; 17–45 min, recovery after hypoxia. a Time courses of ATP usage and ATP production by oxidative phosphorylation and creatine kinase (CK); b time courses of ATP, ADP, PCr, P _i, and pH