Fig. 1
From: Lateral diffusion of manganese in the rat brain determined by T1 relaxation time measured by 1H MRI
The three-dimensional structure of the rat ventricular system and the ROI used for the measurement of manganese diffusion. a, b, c show dorsal (a), frontal (b), and lateral (c) views of the right half of the ventricular system. Ventricles are depicted by 3D gradient-echo images obtained during the ventricular infusion of Gd-DTPA. The three boxes indicate the position and size of the ROI shown in d. d A T1-weighted coronal gradient-echo image of a rat brain at 1 mm caudal to the bregma. The artifact (black round shape) in the image, in the left ventricle, is the tip of the injection cannula. Since Mn-bicine had already been injected, the CSF in the ventricle was depicted as a high intensity. The black horizontal bar represents the ROI, 9 pixels (195 × 1758 μm), perpendicular to the 3rd ventricle, used to measure Mn2+ diffusion. The abbreviations used are as follows: LV left side of the lateral ventricle, 3V the third ventricle, Aq the ventricular aqueduct, and 4V the fourth ventricle