Fig. 2
From: Human urate transporter 1 (hURAT1) mediates the transport of orotate
Effects of various substrates on orotate uptake via hURAT1. HEK-URAT1 cells were incubated in a solution containing 50 nM [3H]orotate at 37°C for 2 min in the absence (open column) or presence (closed column) of several urate-related compounds (100 μM). Each value represents the mean ± SEM of four determinations. **P < 0.01; ***P < 0.001 versus control