Fig. 4

Effect of SOCS-3 partial blockade upon AngII-elicited SOCS-3 drinking behavior of SHR. Two groups of rats (a, b) were i.c.v. cannulated and received either SOCS-3 antisense or SOCS-3 sense phosphorothioate-modified oligonucleotides (4.0 nmol in 3.0 μl solution). Thirty minutes after SOCS-3 antisense or sense, a dose of AngII (40 pmol) was injected and water intake was measured over the next 30 min. In all experiments n = 5; *P ≤ 0.05 versus No oligo (no oligonucleotides) (ANOVA and Bonferroni’s contrast test)