Fig. 5
a Representative recording showing the effect of 10−6 M VIP on 10−6 M PE pre-contracted in the presence of glibenclamide (Glib) in ED rings (n = 10). b Representative recording showing the effect of 10−6 M VIP on 10−6 M PE pre-contracted in the presence of H-89 in ED rings (n = 9). c The ED ring relaxation by 10−6 M VIP was significantly reduced by the 30-min pretreatment with 10−5 M glibenclamide or 5 × 10−7 M H-89, respectively. Responses are expressed as percentage of the active tension originally generated by 10−6 M PE. Data were expressed as mean ± SE. *P < 0.05; **P < 0.01 versus control group