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Table 3 Parameters of the static characteristics of the carotid sinus baroreflex

From: Open-loop dynamic and static characteristics of the carotid sinus baroreflex in rats with chronic heart failure after myocardial infarction

 

Control (n = 12)

CHF (n = 7)

P value

Neural arc

 P1, response range (%)

62 ± 4

42 ± 6**

0.008

 P2, slope coefficient (mmHg−1)

0.10 ± 0.01

0.16 ± 0.03*

0.048

 P3, midpoint pressure (mmHg)

128 ± 4

115 ± 4*

0.043

 P4, minimum SNA (%)

39 ± 4

60 ± 6**

0.008

 Maximum slope (% mmHg−1)

1.62 ± 0.27

1.54 ± 0.27

0.839

Peripheral arc

 a, slope (mmHg %−1)

1.10 ± 0.08

0.75 ± 0.10*

0.013

 b, AP intercept (mmHg)

23.5 ± 7.7

40.7 ± 7.2

0.152

Total baroreflex

 P1, response range (mmHg)

64 ± 4

31 ± 6**

<0.001

 P2, slope coefficient (mmHg−1)

0.10 ± 0.01

0.13 ± 0.01

0.144

 P3, midpoint pressure (mmHg)

122 ± 3

117 ± 4

0.326

 P4, minimum AP (mmHg)

74 ± 4

85 ± 3

0.065

 Maximum gain

1.62 ± 0.22

0.95 ± 0.17*

0.048

Heart rate control

 P1, response range (beats min−1)

49 ± 5

30 ± 6*

0.033

 P2, slope coefficient (mmHg−1)

0.10 ± 0.01

0.13 ± 0.01

0.099

 P3, midpoint pressure (mmHg)

131 ± 4

117 ± 4*

0.046

 P4, minimum HR (beats min−1)

383 ± 7

343 ± 13*

0.011

 Maximum slope (beats min−1 mmHg−1)

1.28 ± 0.23

0.93 ± 0.20

0.313

Equilibrium diagram

 Operating-point AP (mmHg)

116 ± 3

106 ± 3*

0.042

 Operating-point SNA (%)

84 ± 3

90 ± 4

0.227

 Operating-point total baroreflex gain

1.23 ± 0.28

0.96 ± 0.39

0.578

  1. Data are presented as mean ± SE
  2. ** P < 0.01 and *P < 0.05 by unpaired t test