Fig. 5
From: HCO3 −-dependent transient acidification induced by ionomycin in rat submandibular acinar cells
Effects of MIA and DIDS on pHi changes induced by 5 μM IM. a MIA (10 μM, an inhibitor of Na+/H+ exchange) has no effect on pHi. Re-introduction of Ca2+ induced a rapid pHi decrease followed by a rapid pHi increase. The pHi decrease stimulated by 5 μM IM was enhanced by MIA in submandibular acinar cells. b DIDS (200 μM, an inhibitor of Cl−/HCO3 − exchange and Na+-HCO3 − cotransport). DIDS did not inhibit the rapid transient pHi decrease. The pHi increase after the pHi decrease seems to be faster with DIDS than that without DIDS