Fig. 3
From: HCO3 −-dependent transient acidification induced by ionomycin in rat submandibular acinar cells
Intracellular pH (pHi) changes induced by thapsigargin (TG). a HCO3 − containing solution. TG (4 μM) induced no pHi decrease in Ca2+-free solution. The re-introduction of Ca2+ induced a gradual pHi decrease without any rapid pHi increase. b HCO3 −-free solution. The switch to HCO3 −-free solution, increased pHi transiently, and it then plateaued (pHi 7.5). The switch to Ca2+-free solution and addition of IM (1 μM) did not change pHi. The re-introduction of Ca2+ induced a gradual pHi decrease without any pHi increase