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Table 3 Correlations between the dyspnea-slope before and after the break point in the dyspnea-\( \dot{V} {\text{O}}_{2} \) relationship during exercise

From: Exertional dyspnea-related acidotic and sympathetic responses in patients with sequelae of pulmonary tuberculosis

 

Control subjects (n = 9)

TBsq patients (n = 49)

Before the break point

After the break point

Before the break point

After the break point

r

p value

r

p value

r

p value

r

p value

pH-slope

0.528

NS

−0.095

NS

−0.616

<0.0001

−0.629

<0.0001

PaO2-slope

0.093

NS

−0.025

NS

−0.328

0.0209

−0.359

0.0108

PaCO2-slope

−0.145

NS

−0.701

0.0330

0.513

0.0001

0.583

<0.0001

LT-slope

−0.479

NS

0.270

NS

0.542

<0.0001

0.498

0.0002

NE-slope

−0.305

NS

0.689

0.0393

0.443

0.0012

0.643

<0.0001

HR-slope

−0.090

NS

−0.177

NS

0.363

0.0098

0.325

0.0224

f-slope

0.014

NS

−0.129

NS

0.188

NS

0.099

NS

VT-slope

0.059

NS

0.088

NS

−0.160

NS

−0.142

NS

  1. The exercise-response slopes were calculated when the parameters were plotted against \( \dot{V} {\text{O}}_{ 2} \) from rest to the break point, or from the break point to the peak exercise point using linear regression analysis for each subject
  2. TBsq, sequelae of pulmonary tuberculosis; \( \dot{V} {\text{O}}_{ 2} \) oxygen uptake; the break point, the dyspnea-\( \dot{V} {\text{O}}_{ 2} \) break point determined by each subject; PaO2, arterial oxygen tension; PaCO2, arterial carbon dioxide tension; LT, plasma lactate level; NE, plasma norepinephrine level
  3. Dyspnea-slope (∆Borg scale/\( \Updelta \dot{V}_{\text{E}} \)) is expressed as L−1 min, pH-slope (∆pH/\( \Updelta \dot{V} {\text{O}}_{ 2} \)) as L−1 min, PaO2-slope (∆PaO2/\( \Updelta \dot{V} {\text{O}}_{ 2} \)) as mmHg L−1 min, PaCO2-slope (∆PaCO2/\( \Updelta \dot{V} {\text{O}}_{ 2} \)) as mmHg L−1 min, LT-slope (∆LT/\( \Updelta \dot{V} {\text{O}}_{ 2} \)) as mg dL−1 L−1 min, NE-slope (∆NE/\( \Updelta \dot{V} {\text{O}}_{ 2} \)) as ng mL−1 L−1 min, HR-slope (∆Heart rate/\( \Updelta \dot{V} {\text{O}}_{ 2} \)) as beats L−1, f-slope (∆breathing frequency/\( \Updelta \dot{V} {\text{O}}_{ 2} \)) as breaths L−1, V T-slope (∆tidal volume/\( \Updelta \dot{V} {\text{O}}_{ 2} \)) as mL L−1 min
  4. NS not significant