Fig. 4
Effects of the BKCa blocker paxilline (500 nM) on outward potassium currents in thoracic aorta SMC obtained at a potential +70 mV from healthy and irradiated rats treated and not treated with hMSC. a, b Original traces for healthy cells before and after hMSC administration; c, d original traces for irradiated cells before and after hMSC administration (1 initial current, 2 current after paxilline treatment, 3 paxilline + tetraethylammonium in the external bath solution); e diagrams showing effects of paxilline and tetraethylammonium on outwards potassium currents in intact and irradiated SMC treated and not treated with hMSC. Asterisks P < 0.05 versus control; daggers P < 0.05, comparison between irradiated SMC and irradiated SMC treated with hMSC