Fig. 2

Representative histological photomicrographs of inter-acinar pulmonary arterioles (diameter ≤100 μm) from 10-month-old male beagles (20 arterioles/dog were assessed). a A small interalveolar artery from a normal beagle’s lung. The lumen of the arteries is surrounded by thin vessel wall without evident medium and adventicium. b A muscularized interalveolar artery in a treated beagle’s lung. Medial (arrow) hypertrophy and adventitial (arrowhead) fibrosis were observed. c Quantitative analysis of pulmonary arteriole medial wall thickness before and 6 weeks after DHMC. Data are mean ± SD. *p < 0.05 versus baseline. (Scale bars 50 μm)