Fig. 8

SOCE dependence on extracellular Na⁺. a The activation-inhibition cycle on Ca²⁺ entry by SOCE when external Na⁺ is substituted by Tris or exposed to the Na⁺/Ca²⁺ exchange inhibitor KB-R7943. b Changes in cytoplasmic Na⁺ in a similar experiment carried out in a different fiber loaded with Na⁺ indicator SBFI. The figure demonstrates that following depletion, SOCE activation causes simultaneous increases in cytoplasmic Ca²⁺ and Na⁺