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Table 3 Simulated hemodynamic responses of a normal person, a patient with heart failure, and a patient with heart failure with an LVAD operating in co-pulsation, counter-pulsation, and continuous flow modes

From: Computational analysis of the effect of the type of LVAD flow on coronary perfusion and ventricular afterload

 

Normal

HF

LVAD-implanted HF

Co

Counter

Cont

LVAD flow (ml/min)

0

0

5,000

5,000

5,000

Native cardiac output (ml/min)

5,478

3,826

0

0

0

Stroke volume (ml)

76

37

0

0

0

Blood flow: lca (ml/min)

247

156

298

314

302

Blood flow: up (ml/min)

1,418

1,105

1,221

1,218

1,217

Blood flow: sp (ml/min)

1,857

1,427

1,574

1,571

1,568

Blood flow: ll (ml/min)

1,510

1,173

1,296

1,293

1,292

Blood flow: kid (ml/min)

693

552

599

597

597

MAP (mmHg)

100

71

89

89

89

Pulse aortic pressure (mmHg)

31

21

17

17

0

LV peak pressure (mmHg)

117

82

62

43

51

Heart rate (bpm)

72

103

93

93

93

Peripheral resistance: up (%)

100

105

99

98

98

Peripheral resistance: sp (%)

100

107

98

97

98

Peripheral resistance: ll (%)

100

106

98

98

98

Peripheral resistance: kid (%)

100

102

99

99

99

ZPFV: up (%)

100

98

100

100

100

ZPFV: sp (%)

100

97

100

100

100

ZPFV: ll (%)

100

97

100

100

100

ZPFV: kid (%)

100

98

100

100

100

  1. HF Heart-failure patient, Co co-pulsation, Counter counter-pulsation, Cont continuous, lca left coronary artery, up upper body, sp splanchnic, ll lower limbs, kid kidney, MAP mean arterial pressure, LV left ventricle, ZPFV zero-pressure filling volume