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Table 3 Competition of various ligands for specific 125I-Mel binding in NIH3T3 cells transfected with either rat MT1 or MT2 cDNA

From: Gene structures, biochemical characterization and distribution of rat melatonin receptors

Compound K i Ratio (MT2/MT1)
MT1 MT2
I-Mel 6.22 ± 0.57 pM 4.81 ± 0.42 pM 0.77
Melatonin 290 ± 31 pM 378 ± 23 pM 1.31
6-Hydroxymelatonin 118 ± 68 nM 31.7 ± 4.9 nM 0.27
Luzindole 1.15 ± 0.19 μM 433 ± 138 nM 0.38
NAS 1.65 ± 0.42 μM 4.98 ± 2.84 μM 3.00
  1. The K i values are mean ± SEM of four experiments for each compound
  2. I-Mel 2-iodomelatonin, NASN-acetyl-5-hydroxytryptamine