Table 3 Competition of various ligands for specific 125I-Mel binding in NIH3T3 cells transfected with either rat MT1 or MT2 cDNA
From: Gene structures, biochemical characterization and distribution of rat melatonin receptors
Compound | K i | Ratio (MT2/MT1) | |
|---|---|---|---|
MT1 | MT2 | ||
I-Mel | 6.22 ± 0.57 pM | 4.81 ± 0.42 pM | 0.77 |
Melatonin | 290 ± 31 pM | 378 ± 23 pM | 1.31 |
6-Hydroxymelatonin | 118 ± 68 nM | 31.7 ± 4.9 nM | 0.27 |
Luzindole | 1.15 ± 0.19 μM | 433 ± 138 nM | 0.38 |
NAS | 1.65 ± 0.42 μM | 4.98 ± 2.84 μM | 3.00 |