Gastric acid secretion in cholecystokinin-1 receptor, -2 receptor, and -1, -2 receptor gene knockout mice

Table 2 Incremental gastric acid secretion (μmol/60 min per 10 g body weight) stimulated by 1.0 mg/kg histamine, 10 μg/kg carbachol, and 1.0 mg/kg histamine + 10 μg/kg carbachol

Genotype	Histamine alone	Carbachol alone	Histamine + carbachol
Wild-type	2.47 ± 0.40 (11)	5.76 ± 1.60 (9)	11.06 ± 1.88 (8)**
Wild-type	2.47 ± 0.40 (11)	5.76 ± 1.60 (9)	F(2,25) = 11.06, P < 0.0004
CCK-1R(−/−)	1.75 ± 0.62 (6)	5.27 ± 1.05 (6)*	9.98 ± 1.24 (7)**
CCK-1R(−/−)	1.75 ± 0.62 (6)	5.27 ± 1.05 (6)*	F(2,16) = 16.18, P < 0.0001
CCK-2R(−/−)	2.12 ± 0.69 (8)*	0.31 ± 0.15 (7)	3.75 ± 0.29 (5)**
CCK-2R(−/−)	2.12 ± 0.69 (8)*	0.31 ± 0.15 (7)	F(2,17) = 10.08, P < 0.0015
CCK-1R(−/−)2R(−/−)	2.10 ± 0.77 (10)	0.37 ± 0.28 (6)	4.28 ± 1.02 (7)***
CCK-1R(−/−)2R(−/−)	2.10 ± 0.77 (10)	0.37 ± 0.28 (6)	F(2,20) = 5.03, P < 0.017

Values are means ± SE; numbers in the parentheses are the number of animals. The estimation methods are described in the text
* Significantly higher than the value of either histamine alone or carbachol alone, ** significantly higher than other two values, and *** significantly higher than the value produced by carbachol alone by the multiple comparison test

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