Fig. 1

Changes in gastric acid secretion in response to graded doses of carbachol (10, 50, and 100 μg/kg) in wild-type (a), CCK-1R(−/−) (b), CCK-2R(−/−) (c), and CCK-1R(−/−)2R(−/−) mice (d). The results of statistical analyses with respect to time are shown in the text. Asterisks indicate a significant difference from the respective value before carbachol injection by the multiple comparison test. The numbers of animals were 5–9 for each treatment. The arrows indicate the carbachol injection