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Volume 65 Supplement 2

8th FAOPS Congress, November 22–25, 2015, Bangkok, Thailand

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Antinociceptive effects of Rhus coriaria L. extract in male rats

The Journal of Physiological Sciences volume 65, pages S23–S28 (2015)Cite this article

Abstract

It is well known that the tendency toward the medicinal plants is increasing in recent years. They have low side-effects and high varieties of efficient components. This study was designed to investigate the analgesic effect of hydro alcoholic leaf extract of Rhus coriaria (HRCLE) in a rat model. For this purpose, 42 adult male rats were divided into 7 groups: control, HRCLE (80, 100 and 300 mg/kg, i.p.), morphine (1 mg/kg, i.p.), aspirin (1 mg/kg, i.p.), and HRCLE 300 mg/kg plus naloxone (1 mg/kg, i.p.). The analgesic effects of HRCLE were assessed with writhing, tail flick and formalin tests. The data were compared with control by one-way ANOVA and Tukey post hoc test. All dose levels of HRCLE inhibited the number of contractions induced by acetic acid in the writhing test signfiicantly. None of the dose levels of HRCE have been showed antinociceptive activity in the formalin test except the dose of 100 mg/kg (at chronic phase) and the dose of 300 mg/kg (at chronic- acute phase). In the tail flick model, the highest effect was at the dose of 300 mg/kg of HRCLE (P < 0.01). Utilization of naloxone plus extract inhibited the antinociceptive effect of HRCLE. In this study, our findings suggest that analgesic effect for the HRCLE may be mediated via both peripheral and central mechanisms. The presence of flavonoids might be responsible for the antinociceptive activity of this plant.

References

  1. Baker MD, JN Wood (2001) Involvement of Na+ channels in pain pathways. Trends Pharmacol Sci 22(1): 27–31.

    Article  CAS  Google Scholar 

  2. Javan M, et al. (1997) Antinociceptive effects of Trigonella foenum-graecum leaves extract. J Ethnopharmacol 58(2): 125–129.

    Article  CAS  Google Scholar 

  3. Nafisy A (1997) A review of traditional medicine in iran. Isfahan University Publications Isfahan 8(11): 121.

    Google Scholar 

  4. Neto A, et al. (2005) Analgesic and anti-inflammatory activity of a crude root extract of Pfaffia glomerata (Spreng) Pedersen. J Ethnopharmacol 96(1): 87–91.

    Article  CAS  Google Scholar 

  5. Zarei M, et al. (2015) The Antinociceptive Effects of Hydroalcoholic Extract of Bryonia dioica in Male Rats.

    Book  Google Scholar 

  6. Mohammadi S, et al. (2015) In Vivo Antinociceptive Effects of Persian Shallot (Alliumhirtifolium) in Male Rat.

    Google Scholar 

  7. Kossah R, et al. (2009) Comparative study on the chemical composition of Syrian sumac (Rhus coriaria L.) and Chinese sumac (Rhus typhina L.) fruits. Pakistan Journal of Nutrition, 8(10): 1570–1574.

    Article  CAS  Google Scholar 

  8. Wetherilt H, M Pala (1994) Herbs and spices indigenous to Turkey, Amsterdam: Elsevier Science BV.

    Google Scholar 

  9. Andrade SF, et al. (2007) Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea. J Ethnopharmacol 109(3): 464–71.

    Article  CAS  Google Scholar 

  10. Duke JA (2002) Handbook of medicinal herbs: CRC press.

    Book  Google Scholar 

  11. Brunke EJ, et al. (1993) The essential oil of Rhus coriaria L. fruits. Flavour and fragrance journal 8(4): 209–214.

    Article  CAS  Google Scholar 

  12. Nasar-Abbas S, AK Halkman (2004) Antimicrobial effect of water extract of sumac (Rhus coriaria L.) on the growth of some food borne bacteria including pathogens. International Journal of Food Microbiology 97(1): 63–69.

    Article  CAS  Google Scholar 

  13. Özcan M, H Haciseferogullari (2004) A condiment [sumac (Rhus coriaria L.) fruits]: some physicochemical properties. Bulgarian Journal of Plant Physiology 30(3-4): 74–84.

    Google Scholar 

  14. Kosar M, et al. (2007) Antioxidant activity and phenolic composition of sumac (Rhus coriaria L.) extracts. Food Chemistry 103(3): 952–959.

    Article  CAS  Google Scholar 

  15. Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16(2): 109–110.

    Article  CAS  Google Scholar 

  16. Collier H, et al. (1968) The abdominal constriction response and its suppression by analgesic drugs in the mouse. British journal of pharmacology and chemotherapy 32(2): 295–310.

    Article  CAS  Google Scholar 

  17. Gawade S (2012) Acetic acid induced painful endogenous infliction in writhing test on mice. Journal of Pharmacology and Pharmacotherapeutics 3(4): 348.

    Article  Google Scholar 

  18. D’amour FE, DL Smith (1941) A method for determining loss of pain sensation. Journal of Pharmacology and Experimental Therapeutics 72(1): 74–79.

    Google Scholar 

  19. Dubuisson D and SG Dennis (1978) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4: 161–174.

    Article  Google Scholar 

  20. Lorke D (1983) A new approach to practical acute toxicity testing. Archives of toxicology 54(4): 275–287.

    Article  CAS  Google Scholar 

  21. Russo S (2008) Integrated pain management: using omega 3 fatty acids in a naturopathic model. Techniques in Regional Anesthesia and Pain Management 12(2): 105–108.

    Article  Google Scholar 

  22. Fiorucci S, E. Antonelli, and A. Morelli (2001) Mechanism of non-steroidal anti-inflammatory drug-gastropathy. Digestive and Liver Disease 33: S35–S43.

    Article  CAS  Google Scholar 

  23. Negus SS, et al. (2006) Preclinical assessment of candidate analgesic drugs: recent advances and future challenges. Journal of Pharmacology and Experimental Therapeutics 319(2): 507–514.

    Article  CAS  Google Scholar 

  24. Koster R, M Anderson, E De Beer. Acetic acid-induced analgesic screening. (1959) Federation Proceedings.

    Google Scholar 

  25. Jensen TS, TL Yaksh (1986) I. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat. Brain research 363(1): 99–113.

    Article  CAS  Google Scholar 

  26. Tjølsen A, et al. (1992) The formalin test: an evaluation of the method. Pain 51(1): 5–17.

    Article  Google Scholar 

  27. Shibata M, et al. (1989) Modified formalin test: characteristic biphasic pain response. Pain 38(3): 347–352.

    Article  CAS  Google Scholar 

  28. Verma PR, et al. (2005) Antinociceptive activity of alcoholic extract of Hemidesmus indicus R. Br. in mice. J Ethnopharmacol 102(2): 298–301.

    Article  Google Scholar 

  29. Borras M, et al. (2004) fMRI measurement of CNS responses to naloxone infusion and subsequent mild noxious thermal stimuli in healthy volunteers. Journal of neurophysiology 91(6): 2723–2733.

    Article  CAS  Google Scholar 

  30. Hashemi SR, et al. (2008) Acute toxicity study and phytochemical screening of selected herbal aqueous extract in broiler chickens. International Journal of pharmacology 4(5): 352–360.

    Article  Google Scholar 

  31. Abu-Reidah IM, et al. (2015) HPLC-DAD-ESI-MS/MS screening of bioactive components from Rhus coriaria L.(Sumac) fruits. Food Chemistry 166: 179–191.

    Article  CAS  Google Scholar 

  32. Abu-Reidah IM, RM Jamous, MS Ali-Shtayeh (2014) Phytochemistry, Pharmacological Properties and Industrial Applications of Rhus coriaria L.(Sumac). Jordan Journal of Biological Sciences 7(4).

    Google Scholar 

  33. Di Carlo G, et al. (1999) Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life sciences 65(4): 337–353.

    Article  Google Scholar 

  34. Hashemi SR, H Davoodi (2011) Herbal plants and their derivatives as growth and health promoters in animal nutrition. Veterinary Research Communications 35(3): 169–180.

    Article  Google Scholar 

  35. Woodman OL, EC Chan (2004) Vascular and anti-oxidant actions of flavonols and flavones. Clinical and Experimental Pharmacology and Physiology 31(11): 786–790.

    Article  CAS  Google Scholar 

  36. Starec M, D Waitzova, J Elis (1988) Evaluation of the analgesic effect of RG-tannin using the “hot plate” and “tail flick” method in mice. Ceskoslovenská farmacie 37(7): 319.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Biology, Faculty of Basic Sciences, Islamic Azad University of Hamadan, Hamadan, Iran

    Saeed Mohammadi

  2. Department of Physiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Mohammad Zarei

  3. Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Alborz, Iran

    Mohammad Mahdi Zarei

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  1. Saeed Mohammadi
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  2. Mohammad Zarei
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  3. Mohammad Mahdi Zarei
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Correspondence to Mohammad Zarei.

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Mohammadi, S., Zarei, M. & Zarei, M.M. Antinociceptive effects of Rhus coriaria L. extract in male rats. J Physiol Sci 65 (Suppl 2), S23–S28 (2015). https://doi.org/10.1007/BF03405852

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  • DOI: https://doi.org/10.1007/BF03405852

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The Journal of Physiological Sciences

ISSN: 1880-6562

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