Skip to main content
Download PDF

Volume 65 Supplement 2

8th FAOPS Congress, November 22–25, 2015, Bangkok, Thailand

  • Original Paper
  • Published:

Low gamma wave oscillations in the striatum of mice following morphine administration

The Journal of Physiological Sciences volume 65, pages S11–S16 (2015)Cite this article

Abstract

Functional role of the striatum in motor control has been widely studied. In addition, its involvement in reward function as a brain area in the dopamine system has also been mentioned. However, neural signaling in the striatum in response to consumption of emotional enhancing substances remained to be explored. This study aimed to investigate local field potential (LFP) of the striatum following morphine administration. Male Swiss albino mice implanted with electrode into the striatum were given an intraperitoneal injection of either saline or morphine (5 or 15 mg/kg). LFP and locomotor activity of individual animals were simultaneously recorded in the recording chamber following the administration. The inspection of LFP tracings revealed the increase in fast wave induced by morphine particularly at a high dose. Statistical analyses were performed using a one way ANOVA followed by Tukey post hoc test. Frequency analysis using Fast Fourier transform also confirmed a significant elevation of low gamma (30-44.9 Hz) activity. When analyzed in time domain, significant increase in low gamma power was observed from the 15th to 65th min following 15 mg/kg morphine treatment. Moreover, morphine treatment also exhibited a stimulating effect on locomotor speed. However, regression analyses revealed no significant correlation between low gamma power and locomotor speed. In summary, this study demonstrated the increase in low gamma oscillation in the striatum and this effect was not associated with locomotor activity of animals. Thus, it is possible that low gamma oscillation induced by morphine treatment is related with the reward function.

References

  1. Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F (2011) Addiction: Beyond dopamine reward circuitry. PNAS 108(37): 15037–15042.

    Article  CAS  Google Scholar 

  2. Olds J, Milner P (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J Comp Physiol Psychol 47(6): 419–427.

    Article  CAS  Google Scholar 

  3. Spanagel R, Weiss F (1999) The dopamine hypothesis of reward: past and current status. Trends Neurosci 22(11): 521–527.

    Article  CAS  Google Scholar 

  4. Wise RA (2009) Roles for nigrostriatal — not just mesocorticolimbic — dopamine in reward and addiction. Trends Neurosci 32(10): 517–524.

    Article  CAS  Google Scholar 

  5. Wang H-L, Morales M (2008) The corticotropin releasing factor binding protein (CRF-BP) within the ventral tegmental area is expressed in a subset of dopaminergic neurons. J Comp Neurol 509(3): 302–318.

    Article  CAS  Google Scholar 

  6. Fallon JH, Loughlin SE (1995) Substantia nigra. In: Paxinos G (ed) The Rat Nervous System, 2nd edn. Academic Press, New York.

    Google Scholar 

  7. Crow TJ (1972) A map of the rat mesencephalon for electrical self-stimulation. Brain Res 36(2): 265–273.

    Article  CAS  Google Scholar 

  8. Wise RA (1981) Intracranial self-stimulation: mapping against the lateral boundaries of the dopaminergic cells of the substantia nigra. Brain Res 213: 190–194.

    Article  CAS  Google Scholar 

  9. Delgado MR (2007) Reward-related responses in the human striatum. Ann N Y Acad Sci 1104: 70–88.

    Article  Google Scholar 

  10. Cheaha D, Bumrungsri S, Chatpun S, Kumarnsit E (2015) Characterization of in utero valproic acid mouse model of autism by local field potential in the hippocampus and the olfactory bulb. Neurosci Res 98: 28–34.

    Article  CAS  Google Scholar 

  11. Hnasko TS, Sotak BN, Palmiter RD (2005) Morphine reward in dopamine-deficient mice. Nature 438: 854–857.

    Article  CAS  Google Scholar 

  12. Gysling K, Wang RY (1983) Morphine-induced activation of A10 dopamine neurons in the rat. Brain research 277(1): 119–127.

    Article  CAS  Google Scholar 

  13. Chiara GD, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85(14): 5274–5278.

    Article  Google Scholar 

  14. Johnson SW, North R (1992) Opioids excite dopamine neurons by hyperpolarization of local interneurons. J Neurosci 12(2): 483–488.

    Article  CAS  Google Scholar 

  15. Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12(10): 366–375.

    Article  CAS  Google Scholar 

  16. Lotharius J, Brundin P (2002) Pathogenesis of Parkinson’s disease: dopamine, vesicles and α- synuclein. Nat Rev Neurosci 3: 932–942.

    Article  CAS  Google Scholar 

  17. Schultz W (1998) Predictive reward signal of dopamine neurons. J Neurophysiol 80(1): 1–27.

    Article  CAS  Google Scholar 

  18. Sun N, Li Y, Tian S, Lei Y, Zheng J, Yang J, Sui N, Xu L, Pei G, Wilson FAW, Ma Y, Lei H, Hu X (2006) Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal. Neuroscience 138: 77–82.

    Article  CAS  Google Scholar 

  19. Kalenscher T, Lansink CS, Lankelma JV, Pennartz CMA (2010) Reward-associated gamma oscillation in ventral striatum are regionally differentiated and modulate local firing activity. J neurophysiol 103(3): 1658–1672.

    Article  Google Scholar 

  20. Masimore B, Schmitzer-Torbert NC, Kakalios J, Redish AD (2005) Transient gamma local field potential signal movement initiation in rats. Neuroreport 16(18): 2021–2024.

    Article  Google Scholar 

  21. Suto N, Wise RA, Vezina P (2001) Dorsal as well as ventral striatal lesions affect levels of intravenous cocaine and morphine self-administration in rats. Neurosci Lett 493(1-2): 29–32.

    Article  Google Scholar 

  22. Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Childress AR, Jayne M, Ma Y, Wong C (2006) Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction. J Neurosci 26(24): 6583–6588.

    Article  CAS  Google Scholar 

  23. Herrmann CS, Munk MHJ, Engel AK (2004) Cognitive functions of gamma-band activity: memory match and utilization. Trends in cognitive sciences 8(8): 347–355.

    Article  Google Scholar 

  24. Masuda N (2009) Selective population rate coding: a possible computational role of gamma oscillations in selective attention. Neural Comput 21(12): 3335–3362.

    Article  Google Scholar 

  25. Tran AH, Tamura R, Uwana T, Kobayashi T, Katsuki M, Ono T (2005) Dopamine D1 receptors involved in locomotor activity and accumben neural responses to prediction of reward associated with place. PNAS 102(6): 2117–2122.

    Article  CAS  Google Scholar 

  26. Tran AH, Tamura R, Uwana T, Kobayashi T, Katsuki M, Matsumoto G, Ono T (2002) Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice. PNAS 99(13): 8986–8991.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Faculty of Science, Prince of Songkla University (PSU), Hat Yai, Songkhla, 90112, Thailand

    Chayaporn Reakkamnuan, Siriphun Hiranyachattada & Ekkasit Kumarnsit

Authors
  1. Chayaporn Reakkamnuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Siriphun Hiranyachattada
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ekkasit Kumarnsit
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ekkasit Kumarnsit.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Reakkamnuan, C., Hiranyachattada, S. & Kumarnsit, E. Low gamma wave oscillations in the striatum of mice following morphine administration. J Physiol Sci 65 (Suppl 2), S11–S16 (2015). https://doi.org/10.1007/BF03405850

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03405850

Keywords

The Journal of Physiological Sciences

ISSN: 1880-6562

Contact us