Previous Award Winners

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2022
Thermal gradient ring reveals different temperature-dependent behaviors in mice lacking thermosensitive TRP channels
(Tomoyo Ujisawa, Sachiko Sasajima, Makiko Kashio & Makoto Tominaga)

Hypothalamic orexinergic neurons modulate pain and itch in an opposite way: pain relief and itch exacerbation
(Tatsuroh Kaneko, Tomoyuki Kuwaki & Hideki Kashiwadani)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2021
TMC4 is a novel chloride channel involved in high-concentration salt taste sensation
(Yoichi Kasahara, Masataka Narukawa, Yoshiro Ishimaru, Shinji Kanda, Chie Umatani, Yasunori Takayama, Makoto Tominaga, Yoshitaka Oka, Kaori Kondo, Takashi Kondo, Ayako Takeuchi, Takumi Misaka, Keiko Abe & Tomiko Asakura)

Chemogenetic activation of endogenous arginine vasopressin exerts anorexigenic effects via central nesfatin-1/NucB2 pathway
(Kenya Sanada, Mitsuhiro Yoshimura, Naofumi Ikeda, Kazuhiko Baba, Haruki Nishimura, Kazuaki Nishimura, Yuki Nonaka, Takashi Maruyama, Tetsu Miyamoto, Masatomo Mori, Becky Conway-Campbell, Stafford Lightman, Masaharu Kataoka & Yoichi Ueta)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2020
Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice (Shahidul Islam, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Hiroki Yamada, Noriko Takuwa, Yoh Takuwa)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences 2020
Membrane current evoked by mitochondrial Na+–Ca2+ exchange in mouse heart (Mohammed M. Islam, Ayako Takeuchi, Satoshi Matsuoka)

Ionic mechanisms of ST segment elevation in electrocardiogram during acute myocardial infarction (Jun-ichi Okada, Katsuhiko Fujiu, Kazunori Yoneda, Takashi Iwamura, Takumi Washio, Issei Komuro, Toshiaki Hisada, Seiryo Sugiura)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2019
Overexpression of neuronal K⁺–Cl⁻ co-transporter enhances dendritic spine plasticity and motor learning (Kayo Nakamura, Andrew John Moorhouse, Dennis Lawrence Cheung, Kei Eto, Ikuko Takeda, Paul Wiers Rozenbroek, Junichi Nabekura)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences 2019
Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration (Yuko Kato, Utako Yokoyama , Takayuki Fujita, Masanari Umemura, Tetsuo Kubota, Yoshihiro Ishikawa)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2018 
Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist  (So, Mariko; Hashimoto, Hirofumi; Saito, Reiko; Yamamoto, Yukiyo; Motojima, Yasuhito; Ueno, Hiromichi; Sonoda, Satomi; Yoshimura, Mitsuhiro; Maruyama, Takashi; Kusuhara, Koichi; Ueta, Yoichi)

Hypotonicity-induced cell swelling activates TRPA1 (Fujita, Fumitaka; Uchida, Kunitoshi; Takayama, Yasunori; Suzuki, Yoshiro; Takaishi, Masayuki; Tominaga, Makoto)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences 2018
Epac activation inhibits IL-6-induced cardiac myocyte dysfunction  (Jin, Huiling; Fujita, Takayuki; Jin, Meihua; Kurotani, Reiko; Hidaka, Yuko; Cai, Wenqian; Suita, Kenji; Prajapati, Rajesh; Liang, Chen; Ohnuki, Yoshiki; Mototani, Yasumasa; Umemura,Masanari; Yokoyama, Utako; Sato, Motohiko; Okumura, Satoshi; Ishikawa, Yoshihiro)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2017
Nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors (Mami Noda, Ai Kobayashi)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences 2017
Interactions between β-adrenergic vasodilation and cervical sympathetic nerves are mediated by α2-adrenoceptors in the rat masseter muscle (Hisayoshi Ishii, Toshiya Sato)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2016 
Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8 (Masayuki Takaishi, Kunitoshi Uchida, Yoshiro Suzuki, Hiroshi Matsui, Tadashi Shimada, Fumitaka Fujita, Makoto Tominaga)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences 2016 
Partial cavopulmonary assist from the inferior vena cava to the pulmonary artery improves hemodynamics in failing Fontan circulation: a theoretical analysis (Shuji Shimizu, Toru Kawada, Dai Une, Masafumi Fukumitsu, Michael James Turner, Atsunori Kamiya, Toshiaki Shishido, Masaru Sugimachi)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2015
Early-life stress increases the motility of microglia in adulthood (Yusuke Takatsuru, Junichi Nabekura, Tatsuya Ishikawa, Shin-ichi Kohsaka, Noriyuki Koibuchi)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences 2015
Differential contribution of aortic and carotid sinus baroreflexes to control of heart rate and renal sympathetic nerve activity (Kei Ishii, Idesako Mitsuhiro, Kanji Matsukawa)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2014
Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats (Mitsuhiro Yoshimura, Marina Hagimoto, et al.)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences 2014
Discharges of aortic and carotid sinus baroreceptors during spontaneous motor activity and pharmacologically evoked pressor interventions (Kanji Matsukawa , Kei Ishii, Akito Kadowaki, Tomoko Ishida, Mitsuhiro Idesako, Nan Liang)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2013Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus (Yoshihiro Gocho, Atsushi Sakai, Yuchio Yanagawa, Hidenori Suzuki and Fumihito Saitow)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences, 2013
A new calpain inhibitor protects left ventricular dysfunction induced by mild ischemia-reperfusion (Takeshita D, Tanaka M, Mitsuyama S, Yoshikawa Y, Zhang GX, Obata K, Ito H, Taniguchi S and Takaki M)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2012
Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum (Osamu Ikehara, Hisayoshi Hayashi, Toshiharu Waguri, Izumi Kaji, Shin-ichiro Karaki, Atsukazu Kuwahara and Yuichi Suzuki)

Tactile skin stimulation increases dopamine release in the nucleus accumbens in rats (Kimiko Maruyama, Rie Shimoju, Masato Ohkubo, Hitoshi Maruyama and Mieko Kurosawa)

The effects of gonadal steroid manipulation on the expression of Kiss1 mRNA in rat arcuate nucleus during postnatal development (Ken Takumi, Norio Iijima, Kinuyo Iwata, Shimpei Higo and Hitoshi Ozawa)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences, 2012
Evaluation of left ventricular mechanical work and energetics of normal hearts in SERCA2a transgenic rats (Guo-Xing Zhang, Koji Obata, Daisuke Takeshita, Shinichi Mitsuyama, Tamiji Nakashima, Akio Kikuta, Masumi Hirabayashi, Koichi Tomita, Roland Vetter, Wolfgang H. Dillmann, Miyako Takaki)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2011
Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats (Kinuyo Iwata, Mika Kinoshita, Shunji Yamada, Takuya Imamura, Yoshihisa Uenoyama, Hiroko Tsukamura and Kei-ichiro Maeda)

ATP hydrolysis-dependent asymmetry of the conformation of CFTR channel pore (Oleg V. Krasilnikov, Ravshan Z. Sabirov and Yasunobu Okada)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences, 2011
The beginning of the calcium transient in rat embryonic heart (Takeshi Kobayashi, Sachiko Maeda, Nobutoshi Ichise, Tatsuya Sato, Takehito Iwase, Sumihiko Seki, Yoichi Yamada and Noritsugu Tohse)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences, 2010
Voltage-gated Ca2+ channel mRNAs and T-type Ca2+ currents in rat gonadotropin-releasing hormone neurons (Nobuyuki Tanaka, Hirotaka Ishii, Chengzhu Yin, Makiko Koyama, Yasuo Sakuma and Masakatsu Kato)

Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats (Hirofumi Hashimoto, Hiroki Otsubo, Hiroaki Fujihara, Hitoshi Suzuki, Toyoaki Ohbuchi, Toru Yokoyama, Yoshio Takei and Yoichi Ueta)

Hiroshi and Aya Irisawa Memorial Award for Excellent Papers on Research in Circulation in The Journal of Physiological Sciences, 2010
Open-loop dynamic and static characteristics of the carotid sinus baroreflex in rats with chronic heart failure after myocardial infarction (Toru Kawada, Meihua Li, Atsunori Kamiya, Shuji Shimizu, Kazunori Uemura, Hiromi Yamamoto and Masaru Sugimachi)