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  1. Ketogenic diets (KD) have become popular diet to lose weight. However, the effect of such diets on brain function has not yet been clarified. Thus, we aimed to study the effects of KD on the neurogenesis and a...

    Authors: Irfannuddin Irfannuddin, Siti Fazzaura Putri Sarahdeaz, Krisna Murti, Budi Santoso and Noriyuki Koibuchi
    Citation: The Journal of Physiological Sciences 2021 71:3
  2. We previously established that the non-neuronal cardiac cholinergic system (NNCCS) is equipped with cardiomyocytes synthesizes acetylcholine (ACh), which is an indispensable endogenous system, sustaining cardi...

    Authors: Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Atsushi Kurabayashi, Masayuki Tsuda and Yoshihiko Kakinuma
    Citation: The Journal of Physiological Sciences 2021 71:2
  3. We examined the activities of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) and corticotropin-releasing factor (CRF) neurons in the hypothalamic paraventricular nucleus (PVN) during acute treadmil...

    Authors: Ryoko Morikawa, Natsuko Kubota, Seiichiro Amemiya, Takeshi Nishijima and Ichiro Kita
    Citation: The Journal of Physiological Sciences 2021 71:1
  4. Transient ischemia is an exacerbation factor of Alzheimer’s disease (AD). We aimed to examine the influence of amyloid β (Aβ) deposition around the cerebral (pial) artery in terms of diameter changes in the ce...

    Authors: Nobuhiro Watanabe, Yoshihiro Noda, Taeko Nemoto, Kaori Iimura, Takahiko Shimizu and Harumi Hotta
    Citation: The Journal of Physiological Sciences 2020 70:57
  5. The present study aimed to determine the influence of estradiol (E2) and the interaction with circadian phases on thermoregulatory responses to mild heat in female rats. Heat loss and production during 3-h exposu...

    Authors: Shuri Marui, Yuta Masuda, Issei Kato and Kei Nagashima
    Citation: The Journal of Physiological Sciences 2020 70:56
  6. Aging is associated with a progressive loss of skeletal muscle mass and strength, resulting in frailty and lower quality of life in older individuals. At present, a standard of clinical or pharmacological care...

    Authors: Toshinori Yoshihara and Hisashi Naito
    Citation: The Journal of Physiological Sciences 2020 70:55
  7. Insufficient duration of recovery between resistance exercise bouts reduces the effects of exercise training, but the influence on muscle anabolic responses is not fully understood. Here, we investigated the c...

    Authors: Junya Takegaki, Riki Ogasawara, Karina Kouzaki, Satoshi Fujita, Koichi Nakazato and Naokata Ishii
    Citation: The Journal of Physiological Sciences 2020 70:54
  8. We investigated the relationship between impedance parameters and skeletal muscle function in the lower extremities, as well as the effectiveness of impedance parameters in evaluating muscle quality. Lower ext...

    Authors: Hiroki Sato, Takao Nakamura, Toshimasa Kusuhara, Kobara Kenichi, Katsushi Kuniyasu, Takaki Kawashima and Kozo Hanayama
    Citation: The Journal of Physiological Sciences 2020 70:53
  9. Moesin is a member of the ezrin, radixin and moesin (ERM) proteins that are involved in the formation and/or maintenance of cortical actin organization through their cross-linking activity between actin filame...

    Authors: Tomonori Okazaki, Daichi Saito, Masatoshi Inden, Kotoku Kawaguchi, Sayuri Wakimoto, Takashi Nakahari and Shinji Asano
    Citation: The Journal of Physiological Sciences 2020 70:52
  10. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qingbo Cui, Songbin Fu and Zhaozhu Li
    Citation: The Journal of Physiological Sciences 2020 70:51

    The original article was published in The Journal of Physiological Sciences 2013 63:s12576-013-0251-1

  11. Pseudomonas aeruginosa (PA) is one of the most common bacteria that causes lung infection in hospital. The aim of our study is to explore the role and action mechanism of NK cells in lung PA infection.

    Authors: Ruiqi Jia, Kuili Cui, Zhenkui Li, Yuan Gao, Bianfang Zhang, Zhixia Wang and Junwei Cui
    Citation: The Journal of Physiological Sciences 2020 70:50
  12. Arginine vasopressin (AVP) neurons play essential roles in sensing the change in systemic osmolarity and regulating AVP release from their neuronal terminals to maintain the plasma osmolarity. AVP exocytosis d...

    Authors: Kaori Sato-Numata, Tomohiro Numata, Yoichi Ueta and Yasunobu Okada
    Citation: The Journal of Physiological Sciences 2020 70:49
  13. This study investigated the relationship between olfaction and cognitive function in 12 elderly people (age: 80.9 ± 1.6) living in the community. Olfactory function was assessed by the identification threshold...

    Authors: Sae Uchida, Chiho Shimada, Naoko Sakuma, Fusako Kagitani, Akiko Kan and Shuichi Awata
    Citation: The Journal of Physiological Sciences 2020 70:48
  14. TRPM7, a member of the melastatin subfamily of transient receptor potential channels, is suggested to be a potential candidate for a physiological Mg2+ channel. However, there is no direct evidence of Mg2+ permea...

    Authors: Michiko Tashiro, Masato Konishi, Ryo Kobayashi, Hana Inoue and Utako Yokoyama
    Citation: The Journal of Physiological Sciences 2020 70:47
  15. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with chronic abdominal pain and altered pain processing. The aim of this study was to examine whether attentional processes c...

    Authors: Nabi Rustamov, Alice Wagenaar-Tison, Elysa Doyer and Mathieu Piché
    Citation: The Journal of Physiological Sciences 2020 70:46
  16. Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication of diabetes. The purpose of this study is to find the underlying mechanism for the effects of acupuncture in DPN rats. Rats were ren...

    Authors: He-yong Tang, Fan-jing Wang, Jun-long Ma, Hao Wang, Guo-ming Shen and Ai-juan Jiang
    Citation: The Journal of Physiological Sciences 2020 70:45
  17. Glucose uptake and adenosine triphosphate (ATP) generation are important for the survival and growth of endothelial cells. An increase of glucose uptake under hypoxia was previously shown to be associated with...

    Authors: Abdullah Al Mamun, Hisaki Hayashi, Aya Yamamura, Md Junayed Nayeem and Motohiko Sato
    Citation: The Journal of Physiological Sciences 2020 70:44
  18. The relationship between long-term intensive training and brain plasticity in gymnasts has recently been reported. However, the relationship between abilities in different gymnastic events and brain structural...

    Authors: Makoto Fukuo, Koji Kamagata, Mana Kuramochi, Christina Andica, Hiroyuki Tomita, Hidefumi Waki, Hidenori Sugano, Yuichi Tange, Takumi Mitsuhashi, Wataru Uchida, Yuki Takenaka, Akifumi Hagiwara, Mutsumi Harada, Masami Goto, Masaaki Hori, Shigeki Aoki…
    Citation: The Journal of Physiological Sciences 2020 70:43
  19. Metabolic disorders can induce psychiatric comorbidities. Both brain and neuronal composition imbalances reportedly induce an anxiety-like phenotype. We hypothesized that alterations of localized brain areas a...

    Authors: Ryosuke Ochi, Naoto Fujita, Natsuki Goto, Son Tien Nguyen, Duc Trung Le, Kojiro Matsushita, Taketoshi Ono, Hisao Nishijo and Susumu Urakawa
    Citation: The Journal of Physiological Sciences 2020 70:42
  20. The present study aimed to clarify if stroking stimulation of the skin produces positive emotion in rats. 50-kHz ultrasonic vocalizations (USVs) were recorded as an index of the positive emotion. Stroking stim...

    Authors: Rie Shimoju, Hideshi Shibata, Miyo Hori and Mieko Kurosawa
    Citation: The Journal of Physiological Sciences 2020 70:41
  21. Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–proteasome system (UPS) is recognised as a major intracellular protein degradation system, and its function is important fo...

    Authors: Yasuo Kitajima, Kiyoshi Yoshioka and Naoki Suzuki
    Citation: The Journal of Physiological Sciences 2020 70:40
  22. Signal regulators during early cardiogenetic differentiation for the cellular automaticity are largely unknown. Our investigations were designed to clarify the role of transcription factors and their modulator...

    Authors: Mingqi Zheng, Lin Kang, Tomoko Uchino, Gang Liu, Yan Wang and Katsushige Ono
    Citation: The Journal of Physiological Sciences 2020 70:39
  23. Electrical disparity can induce inefficient cardiac performance, representing an uncoordinated wall motion at an earlier activated ventricular wall: an early shortening followed by a systolic rebound stretch. ...

    Authors: Yohsuke Hayama, Shuji Shimizu, Toru Kawada, Jun Negishi, Heima Sakaguchi, Aya Miyazaki, Hideo Ohuchi, Osamu Yamada, Kenichi Kurosaki and Masaru Sugimachi
    Citation: The Journal of Physiological Sciences 2020 70:38
  24. Although anatomical studies have indicated pudendal motoneurons to give off recurrent collaterals, they are not considered to make synapses onto interneurons, such as Renshaw cells, and rather terminate their ...

    Authors: Ken Muramatsu, Masatoshi Niwa and Sei-Ichi Sasaki
    Citation: The Journal of Physiological Sciences 2020 70:37
  25. ST elevation on an electrocardiogram is a hallmark of acute transmural ischemia. However, the underlying mechanism remains unclear. We hypothesized that high ischemic sensitivities of epicardial adenosine trip...

    Authors: Jun-ichi Okada, Katsuhiko Fujiu, Kazunori Yoneda, Takashi Iwamura, Takumi Washio, Issei Komuro, Toshiaki Hisada and Seiryo Sugiura
    Citation: The Journal of Physiological Sciences 2020 70:36
  26. Cisplatin is one of the most potent anti-cancer drugs, though several side effects can induce stress responses such as activation of the hypothalamic–pituitary adrenal (HPA) axis. Arginine vasopressin (AVP) an...

    Authors: Yasuki Akiyama, Mitsuhiro Yoshimura, Hiromichi Ueno, Kenya Sanada, Kentaro Tanaka, Satomi Sonoda, Haruki Nishimura, Kazuaki Nishimura, Yasuhito Motojima, Reiko Saito, Takashi Maruyama, Keiji Hirata, Yasuhito Uezono and Yoichi Ueta
    Citation: The Journal of Physiological Sciences 2020 70:35
  27. Maternal–fetal calcium (Ca2+) transport in the placenta plays a critical role in maintaining fetal bone mineralization. Mutations in the gene encoding the transient receptor potential cation channel, subfamily V,...

    Authors: Yoshiro Suzuki, Hirotake Sawada, Tomoko Tokumasu, Shigeru Suzuki, Shinsuke Ninomiya, Masaru Shirai, Tokuo Mukai, Claire T. Saito, Gen Nishimura and Makoto Tominaga
    Citation: The Journal of Physiological Sciences 2020 70:33
  28. Primary acute sympathetic activation (PASA) can increase arterial pressure (AP). Under this situation, the kidneys may receive mutually opposing influences from sympathetic activation: a direct anti-diuretic e...

    Authors: Toru Kawada, Yohsuke Hayama, Takuya Nishikawa, Satoru Suehara, Satoshi Sawada, Tetsuo Tanaka, Minako Uenohara and Masaru Sugimachi
    Citation: The Journal of Physiological Sciences 2020 70:32
  29. Thirty sedentary overweight women were randomly assigned to three groups (n = 10), including HIIT + green tea, HIIT + placebo and green tea. The training program included 3 sessions/week HIIT while the supplement...

    Authors: Elham Ghasemi, Mohammad Esmaeil Afzalpour and Shila Nayebifar
    Citation: The Journal of Physiological Sciences 2020 70:31
  30. This study examined the effect of olfactory nerve stimulation on regional cerebral blood flow and assessed the effect of intravenous nicotine administration on this response in anesthetized rats. Regional cere...

    Authors: Sae Uchida and Fusako Kagitani
    Citation: The Journal of Physiological Sciences 2020 70:30
  31. Tolfenamic acid, a nonsteroidal anti-inflammatory drug, alleviated learning and memory deficits and decreased the expression of specificity protein 1 (SP1)-mediated cyclin-dependent kinase-5 (CDK5), a major pr...

    Authors: Huiming Zhang, Xiaojuan Wang, Pu Xu, Xuefei Ji, Tianyan Chi, Peng Liu and Libo Zou
    Citation: The Journal of Physiological Sciences 2020 70:29
  32. The efficacy of insulin-like growth factor 1 (IGF-1) in the treatment of peripheral facial nerve palsy was investigated using an animal model. The facial nerve within the temporal bone was exposed and compress...

    Authors: Motoyasu Sugiyama, Tsukasa Ito, Takatoshi Furukawa, Atsushi Hirayama and Seiji Kakehata
    Citation: The Journal of Physiological Sciences 2020 70:28
  33. Neuropsin is a brain-expressed extracellular matrix serine protease that governs synaptic plasticity through activity-induced proteolytic cleavage of synaptic proteins. Its substrates comprise several molecule...

    Authors: Lina Bukowski, Ana M. F. Chernomorchenko, Anna Starnawska, Ole Mors, Nicklas H. Staunstrup, Anders D. Børglum and Per Qvist
    Citation: The Journal of Physiological Sciences 2020 70:26
  34. We investigated that the effects of hypercapnia-induced elevations in cerebral perfusion during a heat stress on global cerebrovascular responses to an orthostatic challenge. Seven volunteers completed a progr...

    Authors: Manabu Shibasaki, Kohei Sato, Ai Hirasawa, Tomoko Sadamoto, Craig G. Crandall and Shigehiko Ogoh
    Citation: The Journal of Physiological Sciences 2020 70:25
  35. To quantify the dynamics of blood flow in brachial artery (BF-BA) in response to sinusoidal work rate (WR) leg cycling exercises of 2-, 4-, and 6-min periods and to examine their relationship with the forearm ...

    Authors: Kohei Miura, Hideaki Kashima, Anna Oue, Ayaka Kondo, Sachiko Watanabe, Masako Y. Endo and Yoshiyuki Fukuba
    Citation: The Journal of Physiological Sciences 2020 70:23
  36. The skin temperature (Tm) of the orofacial area influences orofacial functions and is related to the blood flow (BF). Marked increases in BF mediated by parasympathetic vasodilation may be important for orofacial...

    Authors: Hanako Ohke, Toshiya Sato, Kohei Mito, Makoto Terumitsu and Hisayoshi Ishii
    Citation: The Journal of Physiological Sciences 2020 70:22
  37. Blood pressure response to head-up tilt (HUT) in 7 healthy subjects and 9 patients before and after coronary artery bypass grafting (CABG) was measured during supine and 15-min 60° HUT. Stroke volume (SV) and ...

    Authors: Shinnosuke Hori, Yoshi-ichiro Kamijo, Mitsuru Yuzaki, Tetsuya Kawabe, Kohei Minami, Yasunori Umemoto, Mao Yokoyama, Hiroyasu Uenishi, Yoshiharu Nishimura, Ken Kouda, Yukio Mikami and Fumihiro Tajima
    Citation: The Journal of Physiological Sciences 2020 70:21
  38. The homeobox-containing gene Csx/Nkx2.5 codes several cardiac transcription factors and plays a critical role in early cardiogenesis. We investigated the effect of Csx/Nkx2.5 on the expression of cardiac ion c...

    Authors: Tomoko Uchino, Ming-Qi Zheng, Yan Wang and Katsushige Ono
    Citation: The Journal of Physiological Sciences 2020 70:20
  39. High-fat diet (HFD) can induce deficits in neural function, oxidative stress, and decrease hippocampal neurogenesis. Hypericum (H.) scabrum extract (Ext) contains compounds that could treat neurological disorders...

    Authors: Ghazaleh Omidi, Arezoo Rezvani-Kamran, Ahmad Ganji, Somayeh Komaki, Farshid Etaee, Masoumeh Asadbegi and Alireza Komaki
    Citation: The Journal of Physiological Sciences 2020 70:19
  40. Class II phosphatidylinositol 3-kinases (PI3K), PI3K-C2α and PI3K-C2β, are involved in cellular processes including endocytosis, cilia formation and autophagy. However, the role of PI3K-C2α and PI3K-C2β at the...

    Authors: Shahidul Islam, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Hiroki Yamada, Noriko Takuwa and Yoh Takuwa
    Citation: The Journal of Physiological Sciences 2020 70:18
  41. The peripheral vestibular organs are sensors for linear acceleration (gravity and head tilt) and rotation. Further, they regulate various body functions, including body stability, ocular movement, autonomic ne...

    Authors: Hironobu Morita, Hiroshi Kaji, Yoichi Ueta and Chikara Abe
    Citation: The Journal of Physiological Sciences 2020 70:17
  42. Respiratory disturbances present in Parkinson’s disease (PD) are not well understood. Thus, studies in animal models aimed to link brain dopamine (DA) deficits with respiratory impairment are needed. Adult Wis...

    Authors: Kryspin Andrzejewski, Monika Jampolska, Małgorzata Zaremba, Ilona Joniec-Maciejak, Paweł M. Boguszewski and Katarzyna Kaczyńska
    Citation: The Journal of Physiological Sciences 2020 70:16
  43. The purpose of the present study was to assess the effect of different water immersion temperatures on handgrip performance and haemodynamic changes in the forearm flexors of males and females. Twenty-nine roc...

    Authors: Jiří Baláš, Jan Kodejška, Dominika Krupková and David Giles
    Citation: The Journal of Physiological Sciences 2020 70:13
  44. Experiments on animal hearts (rat, rabbit, guinea pig, etc.) have demonstrated that mechano-calcium feedback (MCF) and mechano-electric feedback (MEF) are very important for myocardial self-regulation because ...

    Authors: Nathalie A. Balakina-Vikulova, Alexander Panfilov, Olga Solovyova and Leonid B. Katsnelson
    Citation: The Journal of Physiological Sciences 2020 70:12
  45. Pathophysiological functions of chloride intracellular channel protein 3 (CLIC3) in human gastric cancer have been unclear. In the tissue microarray analysis using 107 gastric cancer specimens, CLIC3 expressio...

    Authors: Shunsuke Kawai, Takuto Fujii, Takahiro Shimizu, Kenta Sukegawa, Isaya Hashimoto, Tomoyuki Okumura, Takuya Nagata, Hideki Sakai and Tsutomu Fujii
    Citation: The Journal of Physiological Sciences 2020 70:15
  46. Oral administration of donepezil, a centrally acting acetylcholinesterase inhibitor, improves the survival of rats with chronic heart failure (CHF). The mechanisms of cardioprotective effects of donepezil, how...

    Authors: Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura and Masaru Sugimachi
    Citation: The Journal of Physiological Sciences 2020 70:11
  47. Exercise has been reported to induce autophagy. We hypothesized that exercise preconditioning (EP)-related autophagy in cardiomyocytes could be attributed to intermittent ischemia–hypoxia, allowing the heart t...

    Authors: Jian-Qi Yuan, Yang Yuan, Shan-Shan Pan and Ke Cai
    Citation: The Journal of Physiological Sciences 2020 70:10

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