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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes

Fig. 5

A Piezo1 antagonist prevents the suppression of brown adipocyte differentiation induced by a Piezo1 agonist. A Representative images of Oil Red O staining following application of 10 μM Yoda-1 with or without 20 μM Dooku-1 in differentiated brown adipocytes. Vehicle denotes brown adipocytes in differentiation medium with solvent (0.2% DMSO). Scale bar: 100 μm. B The triglyceride levels following application of 10 μM Yoda-1 with or without 20 μM Dooku-1 in differentiated brown adipocytes. The triglyceride levels were normalized to that in the vehicle (absorbance; 0.194 ± 0.012). Each column represents the mean + SEM of 8 experiments. Statistical significance was assessed using ANOVA followed by two-tailed multiple t-tests with Bonferroni correction. *p < 0.05, vs. Vehicle, #p < 0.05 vs. Yoda-1

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