Fig. 5

Mouse behaviors at noxious cold or hot temperatures. A “Spent time” in the cold temperatures (7.8–18.5 ℃) for wild-type (green, n = 13) and TRPA1^−/− (purple, n = 13) mice under the condition of 7.8–47.2 ℃ in the first 20 min (0–20 min) and the last 20 min (40–60 min) of the experiment. *p < 0.05. B “Moving speed” at the cold temperatures (7.8–18.5 ℃) for wild type (green, n = 13) and TRPA1^−/− (purple, n = 13) under the condition of 7.8–47.2 ℃ during the first 20 min (0–20 min) and the last 20 min (40–60 min) of the experiment. C “Spent time” in the hot temperatures (40.2–54.9 ℃) for wild type (green, n = 11), TRPA1^−/− (purple, n = 10), and TRPV1^−/− (red, n = 11) under the condition of 14.6 ℃ to 54.9 ℃ in the first 20 min (0–20 min) and the last 20 min (40–60 min) of the experiment. *p < 0.05 vs. wild type. D “Moving speed” in hot temperatures (40.2–54.9 ℃) for wild type (green, n = 11), TRPA1^−/− (purple, n = 10), and TRPV1^−/− (red, n = 11) under the condition of 14.6–54.9 ℃ in the first 20 min (0–20 min) and the last 20 min (40–60 min) of the experiment. Error bars represent standard errors of the mean