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Table 1 Parameters of phasic PE-induced contractions of Atg7+/+ SM22α-Cre+ (Atg7+/+) and AtgF/F SM22α-Cre+ (Atg7F/F) aortic segments

From: Mouse aortic biomechanics are affected by short-term defective autophagy in vascular smooth muscle cells

 

Atg7+/+

Atg7F/F

Atg7+/+  + 

L-NAME

Atg7F/F + 

L-NAME

AUC (mN*s)

131 ± 19

121 ± 11

123 ± 15

139 ± 10

Ï„contraction (s)

2.5 ± 0.7

3.2 ± 0.6

2.1 ± 0.2

3.2 ± 0.6

Ï„relaxation (s)

26.8 ± 2.9

67.2 ± 17.2*

39.1 ± 12.9

41.9 ± 1.6

Acontraction (mN)

2.8 ± 0.2

2.7 ± 0.3

2.5 ± 0.2

2.5 ± 0.2

Arelaxation (mN)

− 1.7 ± 0.2

− 2.1 ± 0.3

− 1.8 ± 0.2

− 1.9 ± 0.4

  1. Mean ± SEM (n = 5–7). Experiments were performed in the absence and presence of 300 µM L-NAME. Two-way ANOVA with Sidak post hoc test *p < 0.05 for genotype factor with τrelaxation, p = 0.054 for genotype factor with τcontraction
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The Journal of Physiological Sciences

ISSN: 1880-6562

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