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Fig. 8 | The Journal of Physiological Sciences

Fig. 8

From: Mouse aortic biomechanics are affected by short-term defective autophagy in vascular smooth muscle cells

Fig. 8

PE-induced contractions increased aortic stiffness at low and high stretch pressure independently of autophagy deficiency in VSMCs. Ep was measured in aortas of Atg7+/+ SM22α-Cre+ (+/+) and Atg7F/F SM22α-Cre+ (F/F) mice at 80–120 mmHg stretch (N, a) and 100–140 mmHg stretch (H, b) in the absence (Krebs–Ringer, KR) and presence of 2 µM PE (PEmax). Two-way ANOVA with pressure and genotype effect indicated and with Sidak’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001

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