Fig. 11
Atg7F/F SM22α-Cre+ mice reveal heart failure and premature death starting at an age of 4.5 months. a Quantification of heart weight to tibia length ratio (HW/TL) in Atg7+/+ SM22α-Cre+ (+/+) mice and Atg7F/F SM22α-Cre+ (F/F) at 2 and 5 months of age. Representative images of the heart from an Atg7+/+ SM22α-Cre+ and Atg7F/F SM22α-Cre+ mouse at 5 months (5 M) of age are shown. b Quantification of left ventricular end-diastolic diameter (LV EDD) and left ventricular end-systolic diameter (LV ESD) in Atg7+/+ SM22α-Cre+ (+/+) and Atg7F/F SM22α-Cre+ (F/F) mice at 2 and 5 months of age. c Fractional shortening (FS) in Atg7+/+ SM22α-Cre+ (+/+) and Atg7F/F SM22α-Cre+ (F/F) mice at 2 and 5 months of age. Representative M-mode echocardiography images of Atg7F/F SM22α-Cre+ (F/F) mice at 2 and 5 months of age are shown. d Kaplan–Meier survival curves of Atg7+/+ SM22α-Cre+ (+/+) and Atg7F/F SM22α-Cre+ (F/F) mice. ***p < 0.001 versus +/+