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Fig. 4 | The Journal of Physiological Sciences

Fig. 4

From: MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1

Fig. 4

MiR-18a-3p overexpression inhibits OA progression in vivo. A H&E staining was used to observe pathological changes of synovial tissues in the knee joint of sham-operated control rats and OA rats treated with AAV-miR-NC or AAV-miR-18a-3p. B Safranin O-fast green/hematoxylin was used to stain histologic samples of knee joints of sham-operated control rats and OA rats treated with AAV-miR-NC or AAV-miR-18a-3p. C Serum levels of IL-8, IL-6 and PGE2 in sham-operated control rats and OA rats infected with AAV-miR-NC or AAV-miR-18a-3p were examined by ELISA. D, E Protein levels of matrix metalloproteinases (MMP2, MMP3 and MMP9) in sham-operated control rats and OA rats treated with AAV-miR-NC or AAV-miR-18a-3p were examined by western blotting F miR-18a-3p expression in cartilage tissues of rats of four groups was detected using RT-qPCR. *p  < 0.05, **p  <  0.01, ***p  < 0.001

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