Fig. 1

MiR-18a-3p overexpression improves cartilage matrix remodeling and inflammation in IL-1β-stimulated ATDC5 cells. A MiR-18a-3p expression in ATDC5 cells with or without IL-1β treatment was detected by RT-qPCR. B Transfection efficiency of miR-18a-3p mimics in IL-1β-stimulated ATDC5 cells was detected by RT-qPCR. After IL-1β treatment or miR-18a-3p overexpression, C–E the secretion of inflammatory cytokines IL-8, IL-6 and PGE2 in ATDC5 cells was examined by ELISA. F Protein levels of matrix metalloproteinases (MMP2, MMP3 and MMP9) were examined by western blotting. *p  < 0.05, **p  < 0.01, ***p  < 0.001