Fig. 4
From: Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice
Effect of vidarabine on BO-induced oxidative stress in cardiac muscle. a Representative immunohistochemical images of oxidative DNA damage (8-OHdG) in cardiac muscle in the Control (CTRL; upper left), BO (upper right), vidarabine (V; lower left) and BO + V (lower right) groups. b 8-OHdG-positive nuclei were significantly increased in the BO group (n = 5), but this increase was blocked in the BO + V group (n = 4). *P < 0.05 by one-way ANOVA followed by the Tukey–Kramer post hoc test. c Representative SDS-PAGE of oxidized proteins in cardiac muscle homogenate prepared from Control (CTRL; lane 1), BO (lane 2), V (lane 3) and BO + V (lane 4) groups using the OxiSelectTM Protein Carbonyl Immunoblot Kit. Full-size images of immunoblots are presented in Additional file 1: Fig. S6. d Oxidized proteins were significantly increased in the BO group (n = 5), but this increase was blocked in the BO + V group (n = 4). *P < 0.05, **P < 0.01 by one-way ANOVA followed by the Tukey–Kramer post hoc test. Data are presented as mean ± SD