Fig. 3

Baroreflex equilibrium diagrams constructed from fitted neural and peripheral arcs with (A) or without (B) the peripheral effect of clonidine. PX, the exclusion of the peripheral effect. Labels C, L, H denote the data under control conditions, after low-dose (2 μg/kg) clonidine, and after high-dose (5 μg/kg) clonidine, respectively. The operating-point AP was defined as the AP at the intersection point between the neural and peripheral arcs (the left arrowheads). In panel C, the operating-point AP values are expressed as the box and whisker plots (n = 8). The box indicates the 25th–75th percentile range. The horizontal line in the box indicates the median. The whiskers indicate the minimum and maximum data points. The mean of data points was superimposed in a cross symbol. *P < 0.05, **P < 0.01, and ***P < 0.001 by a Tukey test following one-way repeated-measures analysis of variance