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Fig. 2 | The Journal of Physiological Sciences

Fig. 2

From: Quantitative assessment of the central versus peripheral effect of intravenous clonidine using baroreflex equilibrium diagrams

Fig. 2

Open-loop static characteristics of the total reflex arc (A), HR control (B), neural arc (C), and peripheral arc (D) together with their parameter values (EH). CSP carotid sinus pressure, AP arterial pressure, HR heart rate, SNA sympathetic nerve activity, P1 response range, P2 slope coefficient; P3 midpoint input pressure, P4 lower asymptote of the fitted sigmoid curve. Labels C, L, H denote the data under control conditions, after low-dose (2 μg/kg) clonidine, and after high-dose (5 μg/kg) clonidine, respectively. In panels AD, data are expressed as mean ± SE values (n = 8). The smooth curve or the line was drawn using mean values of fitted parameters. In panels EH, data are expressed as box and whisker plots (n = 8). The box indicates the 25th–75th percentile range. The horizontal line in the box indicates the median. The values above the 75th percentile plus 1.5 times the interquartile range (IQR) or those below the 25th percentile minus 1.5 times IQR are defined as outliers (filled circles). The whiskers indicate the minimum and maximum data points, excluding the outliers. In each plot, the mean of data points was superimposed in a cross symbol. *P < 0.05, **P < 0.01, and ***P < 0.001 by a Tukey test following one-way repeated-measures analysis of variance

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