Fig. 3
From: TMC4 is a novel chloride channel involved in high-concentration salt taste sensation
Loss of TMC4 specifically affects the glossopharyngeal nerve response to high NaCl and KCl. A, B Integral taste nerve response of wild-type (WT) or Tmc4 knock-out (KO) mice to NaCl and KCl solutions (30, 50, 100, and 300 mM). C Responses to the other taste substances: sucrose for sweet, a mixture of monosodium glutamate (MSG) and inosine monophosphate (IMP) for umami, citric acid for sour, denatonium for bitter and amiloride for epithelial sodium channel blocker. The asterisks (*, **, ****) indicate statistical differences: p < 0.05, 0.01, and 0.0001, respectively. Significance was evaluated using two-way ANOVA with Bonferroni correction (n = 6–7 for WT and n = 5–6 for KO)