Fig. 3

Mechanical and heat responses of cutaneous C-fiber afferents. a Representative recording of a C-fiber obtained from the CTR group. b Recording from the IM group. Stimulus outputs of mechanical (294 mN in 30 s) and heat stimuli (from 32 to 50 °C in 30 s) are shown under the original recordings. An inset on the left side of each recording indicates the shape of the individual spike indicated by an arrow. Recordings of mechanical and heat responses are continuous and separated by a double slash (//) at a time interval of 5–10 min