Fig. 1

Individual example of physiological recordings. Representative recordings of MAP, SCBF and LFP responses for the eight stimulus intensities every hour, in one rat that received fluorocitrate. MAP and SCBF responses are a response to a single stimulus. LFP responses represent a mean of 50 responses. The stimulation produced intensity-dependent increases in MAP that remained stable over time and unaffected by fluorocitrate. The stimulation also produced intensity-dependent increases in SCBF. However, response amplitude progressively decreased over time due to the exposure to fluorocitrate. As for LFP, the expected negative and positive deflections were observed with an intensity-dependent amplitude. The peak-to peak amplitude of these deflections was stable over time and unaffected by fluorocitrate. The shaded areas with a horizontal black line (MAP and SCBF) indicate stimulus duration. The vertical grey bars (LFP) indicate the stimulus delivery (one of the 1 ms pulses from the train of 50 pulses)