Skip to main content
Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Successful induction of deep hypothermia by isoflurane anesthesia and cooling in a non-hibernator, the rat

Fig. 5

Effects of recovery of body temperature on serum levels of organ injury markers. Serum levels of AST, ALT, LDH and BUN are shown in panels a–d, respectively. Pre and Post represent the values in rats before and after recovery of body temperature. Warming the rats immediately after the temperature had reached 15 °C (compare black symbols) showed that the recovery process itself significantly increased serum levels of these organ injury markers. When the rats that had been kept in the hypothermic condition for 3 h or 6 h were warmed and allowed to recover, serum levels of AST, ALT, LDH and BUN, which were increased during the maintenance of hypothermia, were further increased (compare red symbols). Two-way ANOVA analyses showed a significant interaction between the effects of the duration of maintenance of hypothermia and effects of the recovery process. Values are means ± SD (n = 5). The blue vertical lines denote statistical significance (p < 0.05). Asterisks denote significant difference between Pre and Post (p < 0.05)

Back to article page