Fig. 1

Pharmacological doses of terbutaline and nifedipine mediate reductions in oxytocin-induced intracellular calcium flux and contractile force in a dose-dependent manner. a Determination of subtherapeutic concentration for nifedipine and terbutaline. Initial dose–response experiments performed to assess significant reductions in intracellular calcium flux mediated by nifedipine (left) and terbutaline (right) demonstrated non-statistical reductions in intracellular calcium at doses up to 10^–9 M. (***p < 0.001, n = 10). b Determination of subtherapeutic concentration for nifedipine and terbutaline. Initial dose–response experiments performed to assess significant reductions in contractility mediated by nifedipine (left) and terbutaline (right) demonstrated non-statistical reductions in force at doses up to 10^–8 M (***p < 0.001, n = 38 samples from 8 different patients)