Table 1 Ki values for EP receptor subtype-specific agonists and antagonists used in the present study
Ki [mol L−1] | ||||
|---|---|---|---|---|
EP1 | EP2 | EP3 | EP4 | |
Agonist | ||||
PGE2 (endogenous) | 2.2 × 10−8 | 6.8 × 10−9 | 9 × 10−10 | 1.1 × 10−9 |
ONO-DI-004 (EP1) | 1.5 × 10−7 | > 10−5 | > 10−5 | > 10−5 |
ONO-AE1-259 (EP2) | > 10−5 | 3 × 10−9 | > 10−5 | 6.0 × 10−6 |
ONO-AE-248 (EP3) | > 10−5 | 3.7 × 10−6 | 7.5 × 10−9 | 4.2 × 10−6 |
ONO-AE1-329 (EP4) | > 10−5 | 2.1 × 10−6 | 1.2 × 10−6 | 9.7 × 10−9 |
Antagonist | ||||
AH6809 (EP1/EP2) | 1.3 × 10−6 | 5.22 × 10−7 | > 10−5 | > 10−5 |
ONO-AE3-208 (EP4) | > 10−5 | > 10−5 | 3 × 10−8 | 1.3 × 10−9 |