Fig. 2

Concentration-dependent inhibitory effects of PGE₂ on GC frequency and amplitude. In the presence of TTX and piroxicam, vehicle control (DMSO) or PGE₂ was added cumulatively to the bathing solution (10⁻¹¹ to 3 × 10⁻⁶ mol L⁻¹) in  ~ 30-min intervals. Representative traces after the addition of DMSO (a) or PGE₂ (b) are shown. Concentration–response curves of the normalized mean frequency and amplitude (see Methods and Results) are shown in c and d. Data are expressed as means ± SE (n = 4)