Fig. 4

Influence of Aβ deposition around the pial artery on arterial diameter changes in response to common carotid artery occlusion. The time course of artery diameter change in each VOI (thin lines) is shown in Fig. 3a (WT mice), and their average (thick line) is presented (a). In this example, a 3D image data were obtained approximately every 16 s. Vessel diameters during carotid artery occlusion and after occlusion re-opening are compared with the diameter before occlusion (b). *p < 0.05; significant difference from the value before the occlusion using paired t test. The box indicates the median and interquartile range (25%–75%) and the end of whiskers indicates the minimum and maximum values in b. c and d show the artery diameter change time course in each VOI illustrated in Fig. 3d from Aβ-absent (Aβ−) site and Aβ-present (Aβ+) site, respectively. In this example, a 3D image data were obtained approximately every 20 s. Diameter changes during carotid artery occlusion are compared (e). Each circle in e indicates data of individual artery. ^#p < 0.05; significant difference using unpaired t test. ^†p < 0.05; significant difference using paired t test. Data are expressed as the median and interquartile range (25–75%) in e