Fig. 1

Prolonged microglial activation of the WT and Msn-KO mice after repeated systemic challenge with LPS. a Immunofluorescence staining of the microglial marker Iba1 in the WT (a, b) and Msn-KO (c, d) mouse SNpc on experimental day 5 after repeated treatment with PBS control (a, c) or LPS (b, d). Representative images of 6 mice are shown. b Quantification of Iba1 staining area shown in a was expressed as the ratio with the value of WT treated with PBS being 1. Results are shown as mean ± SEM. *p < 0.05 vs. PBS, and #p < 0.05 vs. WT treated with PBS (n = 6 animals)