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Table 2 Electrophysiological characteristics of three pacemaker ionic currents and cellular membrane capacitance on the differentiation day 14–17

From: Mitogen-activated protein kinase p38 modulates pacemaker ion channels differentiation in P19-derived pluripotent cells

 

α-MEM

1% Me2SO

1% Me2SO + PD

1% Me2SO + SP

1% Me2SO + SB

ICa.L

0

− 52.1 ± 8.8

− 85.4 ± 10.6

− 1.6 ± 6.4

0

(pA pF−1)

(n = 11)

(n = 19)

(n = 17)*

(n = 11)*

(n = 27)*

ICa.T

0

− 41.4 ± 17.6

− 43.1 ± 10.9

− 42.1 ± 9.5

0

(pA pF−1)

(n = 10)

(n = 17)

(n = 12)

(n = 9)

(n = 21)*

If

0

− 26.9 ± 4.7

− 28.5 ± 3.9

− 37.4 ± 6.3

− 0.1 ± 0.2

(pA pF−1)

(n = 8)

(n = 37)

(n = 16)

(n = 10)*

(n = 25) *

Cm

7.0 ± 1.9

20.1 ± 5.2

21.4 ± 6.8

19.2 ± 7.2

11.9 ± 3.3

(pF)

(n = 11)

(n = 62)

(n = 41)

(n = 41)

(n = 67) *

  1. PD: PD98059, 10 μM; SP: SP600125, 10 μM; SB: SB203580, 10 μM
  2. Cm, cellular membrane capacitance
  3. Mean ± S.E. *p < 0.05 vs. control (1% Me2SO)