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Table 1 Parameters of action potentials on day 14–17

From: Mitogen-activated protein kinase p38 modulates pacemaker ion channels differentiation in P19-derived pluripotent cells

 

α-MEM (n = 14)

1% Me2SO (n = 15)

1% Me2SO + PD (n = 12)

1% Me2SO + SP (n = 11)

1% Me2SO + SB (n = 11)

BR (bpm)

0

89.2 ± 17.4

82.7 ± 11.8

95.7 ± 12.3

–

MDP (mV)

− 51.9 ± 6.7

− 58.6 ± 2.5

− 57.9 ± 1.7

− 58.1 ± 3.1

− 49.0 ± 3.3*

APD50 (ms)

–

138 ± 7

105 ± 9*

149 ± 11

–

APD75 (ms)

–

278 ± 14

299 ± 19

247 ± 17

–

  1. PD: PD98059, 10 μM; SP: SP600125, 10 μM; SB: SB203580, 10 μM
  2. APD50, the duration of 50% repolarization of action potentials
  3. APD75, the duration of 75% repolarization of action potentials
  4. BR beating rates, MDP maximum diastolic potentials
  5. Mean ± S.E. *p < 0.05 vs. control (1% Me2SO)
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The Journal of Physiological Sciences

ISSN: 1880-6562

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