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Fig. 4 | The Journal of Physiological Sciences

Fig. 4

From: Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice

Fig. 4

Attenuated contraction of the aortic rings from DKO mice. a Dose-dependent noradrenaline (NA)- and KCl b-induced isometric contraction of the aortic rings from C2αflox/flox C2β−/− (control) and DKO mice with and without the Rho kinase inhibitor Y-27632 (10 µM) was determined (n = 3 per each group). ★p < 0.05, ★★p < 0.01 and ★★★p < 0.001 compared with control mouse rings

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