Fig. 3From: Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environmentRole of follistatin in the effects of gravity change on muscle and bone. Follistatin suppresses the action of myostatin, an inhibitor of skeletal muscle mass and a stimulator of bone resorption. Hypergravity enhances follistatin expression in skeletal muscles through the vestibular system in mice. Circulating follistatin induced by gravity change might be involved in hypergravity-enhanced bone mass by inhibiting myostatin-induced bone resorptionBack to article page